Game Changing Neoadjuvant Lung Trial Enrolls the Most People in the World
March 16, 2022 – Charleston Oncology’s Clinical Trials most recent non–small cell lung cancer trial enrolled the most people in the world. Gene Saylors, MD, oncologist and hematologist at Charleston Oncology, will present the positive findings at the American Association for Cancer Research 2022 Annual Meeting. “When administering a new trial, we are always cautiously optimistic,” says Dr. Gene Saylors. “The positive results of this Neoadjuvant Lung Trial resulted in rapid FDA approval due to its impressive outcomes.”
Neoadjuvant Opdivo (nivolumab) plus chemotherapy significantly improves event-free survival in patients with resectable Non-Small Cell Lung Cancer in Phase 3 CheckMate -816 Trial. The trial adds immunotherapy and chemotherapy for nine weeks before lung surgery. “The patients who had immunotherapy, when they went to surgery, 24% or nearly 1 in 4, the cancer was all gone. When you just gave chemotherapy for that same duration, in only 2% of the patients was the cancer gone. So, it’s just a game-changer,” Saylors said.
This protocol, called Checkmate 816, delivered significantly better outcomes than patients going straight to surgery. Per Bristol Myers Squibb’s November 2021 published findings, CheckMate -816 is the first Phase 3 trial with an immunotherapy-based combination to demonstrate improved event-free survival and pathologic complete response in the neoadjuvant setting of non-small cell lung cancer.
Positive results reinforce the improved efficacy of Opdivo-based treatments in four Phase 3 clinical trials in earlier-stage cancers, including lung cancer, bladder cancer, esophageal/gastroesophageal junction cancer, and melanoma.
Charleston Oncology provides the largest number of oncology and hematology clinical trials in the greater Charleston area. Located in West Ashley, North Charleston, Mount Pleasant, Downtown Peninsula Charleston, Summerville, and Walterboro, Charleston Oncology is a full-service oncology and hematology practice with eleven physicians. To schedule an appointment or learn more, visit www.CharlestonOncology.com.
Send UsA Message
The Importance of Subspecialization in Oncology: Our Commitment at Charleston Oncology
The Importance of Subspecialization in Oncology: Our Commitment at Charleston OncologyAt Charleston Oncology, we know that a cancer diagnosis can be overwhelming. For most patients, the search for the right doctor quickly becomes one of the most important steps on...
Lung Cancer in Non-Smokers: What You Should Know
Lung Cancer in Non-Smokers: What You Should KnowAt Charleston Oncology, we understand that lung cancer is often linked to smoking, but it’s important to remember that lung cancer can affect anyone, even those who have never smoked. As part of Lung Cancer Awareness...
Why Early Detection Matters: Breast Cancer Screening Guidelines By Age
Why Early Detection Matters: Breast Cancer Screening Guidelines By AgeBreast cancer is the most common cancer diagnosed in women, but it is also one of the most treatable when found early. Early detection is the single most powerful tool we have in the fight against...
Proactive Health: Prostate and Blood Cancer Awareness
Proactive Health: Prostate and Blood Cancer AwarenessTaking charge of your health means being informed and proactive, especially when it comes to cancer prevention and early detection. This September, as we observe both Prostate Cancer Awareness Month and Blood Cancer...
The Patients’ Unique Needs
From diagnosis to treatment and follow-ups, Charleston Oncology, as a part of the Department of Bon Secours St. Francis’ leading multidisciplinary cancer care team, plays a vital role in guiding patients through their breast cancer journey.
Landing on Your Feet: Celebrating Life After Cancer
From diagnosis to treatment and follow-ups, Charleston Oncology, as a part of the Department of Bon Secours St. Francis’ leading multidisciplinary cancer care team, plays a vital role in guiding patients through their breast cancer journey.
